Understanding East-West differences in subsolid nodules: prevalence and overdiagnosis implications in lung cancer screening.

ABSTRACT:

Background

Owing to the widespread opportunistic LDCT screening leading to increased overdiagnosis in Asian countries, such as South Korea, mainland China, and Taiwan, this study seeks to analyze the divergence in SSN prevalence between Eastern and Western nations, focusing on the influence of SSN on the growing overdiagnosis trend, notably among females.

Methods

This retrospective study collected data from 4166 participants who underwent baseline LDCT in a hospital-based cohort between January 2014 and August 2021. Clinical parameters, including age, sex, lung imaging reporting and data system (Lung-RADS) categories, smoking history, pack-year dose, and SSN characteristics, were extracted from electronic medical records. Additionally, a narrative review and pooled analysis

SUBMITTER: Chang YC 

PROVIDER: S-EPMC11912254 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature