Deciphering the causal link between gut microbiota and membranous nephropathy: insights into potential inflammatory mechanisms.

ABSTRACT:

Background

Membranous nephropathy (MN), a leading cause of adult nephrotic syndrome and renal failure, has been linked to gut microbiota (GM) and their metabolites. However, direct causal relationships and therapeutic implications remain unclear.

Methods

We utilized a comprehensive GWAS dataset that encompasses GM, metabolites, and MN through two-sample Mendelian randomization (MR) analyses, bidirectional MR evaluations, and detailed sensitivity tests.

Results

We identified strong causal associations between nine specific types of GM, including class Clostridia (OR = 1.816, 95%CI: 1.021-3.236, p = .042), class Melainabacteria (OR = 0.661, 95%CI: 0.439-0.996, p = .048), order Gastranaerophilales (OR = 0.689, 95%CI: 0.480-0.996, p</

SUBMITTER: Qing J 

PROVIDER: S-EPMC11912295 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature