Leveraging Zebrafish Embryo Phenotypic Observations to Advance Data-Driven Analyses in Toxicology.

ABSTRACT: Zebrafish have emerged as a central model organism in toxicological research. Zebrafish embryos are exempt from certain animal testing regulations, which facilitates their use in toxicological testing. Next to the zebrafish embryo acute toxicity test (ZFET) according to the OECD TG 236, fish embryos are used in mechanistic investigations, chemical screenings, ecotoxicology, and drug development. However, inconsistencies in the applied test protocols and the monitored endpoints in addition to a lack of standardized data formats impede comprehensive meta-analyses and cross-study comparisons. To address these challenges, we developed the Integrated Effect Database for Toxicological Observations (INTOB), a comprehensive data management tool that standardizes the collection of metadata and phen

SUBMITTER: Michaelis P 

PROVIDER: S-EPMC11912306 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature