Structural Influence of the Chemical Fueling System on a Catalysis-Driven Rotary Molecular Motor.

ABSTRACT: Continuous directionally biased 360° rotation about a covalent single bond was recently realized in the form of a chemically fueled 1-phenylpyrrole 2,2'-dicarboxylic acid rotary molecular motor. However, the original fueling system and reaction conditions resulted in a motor directionality of only ∼3:1 (i.e., on average a backward rotation for every three forward rotations), along with a catalytic efficiency for the motor operation of 97% and a fuel efficiency of 14%. Here, we report on the efficacy of a series of chiral carbodiimide fuels and chiral hydrolysis promoters (pyridine and pyridine N-oxide derivatives) in driving improved directional rotation of this motor-molecule. We outline the complete reaction network for motor operation, composed of directional, futile, and slip cy

SUBMITTER: Liu HK 

PROVIDER: S-EPMC11912321 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature