Noninvasive Vagus Nerve Electrical Stimulation for Immune Modulation in Sepsis Therapy.

ABSTRACT: Sepsis presents a significant medical challenge due to its intense inflammatory response to infection, often resulting in high mortality rates. A promising therapeutic strategy targets the cholinergic anti-inflammatory pathway (CAIP), which regulates immune responses. This study investigates the ingestion of piezoelectric particles that adhere to the stomach lining, specifically targeting TRPV1 receptors. In a mouse model of sepsis, these particles, when activated by low-intensity pulsed ultrasound, generate mild electrical pulses. These pulses stimulate vagal afferent fibers, transmitting signals to the brain and modulating the neural-immune network via the CAIP. Consequently, this leads to a reduction in systemic inflammation, mitigating weight loss, alleviating multiple tissue injuries,

SUBMITTER: Mac CH 

PROVIDER: S-EPMC11912339 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature