Mechanical ventilation energy analysis: Recruitment focuses injurious power in the ventilated lung.

ABSTRACT: The progression of acute respiratory distress syndrome (ARDS) from its onset due to disease or trauma to either recovery or death is poorly understood. Currently, there are no generally accepted treatments aside from supportive care using mechanical ventilation. However, this can lead to ventilator-induced lung injury (VILI), which contributes to a 30 to 40% mortality rate. In this study, we develop and demonstrate a technique to quantify forms of energy transport and dissipation during mechanical ventilation to directly evaluate their relationship to VILI. A porcine ARDS model was used, with ventilation parameters independently controlling lung overdistension and alveolar/airway recruitment/derecruitment (RD). Hourly measurements of airflow, tracheal and esophageal pressures, respiratory

SUBMITTER: Gaver DP 

PROVIDER: S-EPMC11912383 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature