EGFR-induced lncRNA <i>TRIDENT</i> promotes drug resistance in non-small cell lung cancer via phospho-TRIM28-mediated DNA damage repair.

ABSTRACT: Long noncoding RNAs (lncRNAs) play numerous roles in cellular biology and alterations in lncRNA expression profiles have been implicated in a variety of cancers. Here, we identify and characterize a lncRNA, TRIM28 Interacting DNA damage repair Enhancing Noncoding Transcript (TRIDENT), whose expression is induced upon epithelial growth factor receptor (EGFR) activation, and which exerts pro-oncogenic functions in EGFR-driven non-small cell lung cancer. Knocking down TRIDENT leads to decreased tumor-cell proliferation in both in vitro and in vivo model systems and induces sensitization to chemotherapeutic drugs. Using ChIRP-MS analysis we identified TRIM28 as a protein interactor of TRIDENT. TRIDENT promotes phosphorylation of TRIM28 and knocking down TRIDENT</

SUBMITTER: Saxena T 

PROVIDER: S-EPMC11912419 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature