The NAE1-mediated neddylation operates as an essential post-translational modification checkpoint for effector CD8⁺ T cells.

ABSTRACT: Optimal activation of CD8+ T cells is crucial for immunity-mediated destruction of cancer, requiring a substantial amount of proteins involved in metabolism, proliferation, and effector function. Despite extensive studies emphasizing the role of transcriptional regulation in this process, paired transcriptomic and proteomic analyses reveal that the RNA profile is poorly correlated with protein levels. This discrepancy underscores the importance of post-translational modifications (PTMs) in controlling protein abundance during activation. However, the impact of PTMs on the CD8+ T cell protein dynamic remains underexplored. We identify that neddylation, a recently discovered PTM, is activated in response to T cell receptor (TCR) stimulation and enriched in effector CD8+ T cells from colon ca

SUBMITTER: Jin J 

PROVIDER: S-EPMC11912420 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature