Genetic ablation of the TET family in retinal progenitor cells impairs photoreceptor development and leads to blindness.

ABSTRACT: The retina is responsible for converting light into electrical signals that, when transmitted to the brain, create the sensation of vision. The mammalian retina is epigenetically unique since the differentiation of retinal progenitor cells (RPCs) into retinal cells is accompanied by a decrease in DNA methylation in the promoters of many genes important for retinal development and function. However, the pathway responsible for DNA demethylation and its role in retinal development and function were unknown. We hypothesized that the Ten-Eleven Translocation (TET) family of dioxygenases plays a key role in this pathway. To this end, we knocked out the TET family in RPCs and characterized the TET-deficient and control retinas using various approaches including electron microscopy, electroretino

SUBMITTER: Dvoriantchikova G 

PROVIDER: S-EPMC11912455 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature