Lipoprotein subclasses and gastrointestinal cancers: novel perspectives and potential associations.

ABSTRACT:

Background

This study aimed to investigate the associations between serum lipoprotein subclasses and the long-term risk of gastrointestinal (GI) cancers to enhance our understanding of the etiology of GI cancers.

Methods

This prospective cohort study included 249,450 participants from the UK Biobank. Cox proportional hazard models were used to assess the association between 17 serum lipoprotein subclasses with the risk of GI cancers. Restricted cubic spline (RCS) analysis was employed to assess the corresponding dose-response relationships. Additionally, Mendelian randomization (MR) analysis was used to evaluate the causal relationships between the lipoproteins and the risk of GI cancers.

Results

A total of 4,787 cases of GI cancers were recorded over a median follow-

SUBMITTER: Yang C 

PROVIDER: S-EPMC11912509 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature