Determining Molecular-Level Interactions of Carboxyl-Functionalized Nanodiamonds with Bacterial Membrane Models as the Basis for Antimicrobial Activity.

ABSTRACT: Carbon-based nanostructures, such as carboxylated nanodiamonds (NDCOOHs), are promising to combat resistant bacterial strains by targeting their protective membranes. Understanding their interactions with bacterial membranes is therefore important for elucidating the mechanisms underlying NDCOOHs antimicrobial activity. In this study, we investigated the incorporation of NDCOOHs into lipid Langmuir monolayers mimicking cytoplasmic membranes of Escherichia coli and Staphylococcus aureus, model systems for Gram-negative and Gram-positive bacteria, respectively. Using polarization-modulated infrared reflection-absorption spectroscopy (PM-IRRAS), we observed significant interactions between NDCOOHs and the polar head groups of the E. coli lipid monolayer, dri

SUBMITTER: Sousa GES 

PROVIDER: S-EPMC11912534 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature