Hydrolytic, Thermal, and Electrochemical Stability of Thiol- and Terminal Alkyne-Based Monolayers on Gold: A Comparative Study.

ABSTRACT: The terminal alkyne-Au interaction is emerging as a promising adsorbing bonding motif for organic monolayers, allowing it to be used for installing antifouling layers and/or recognition elements on gold surfaces for biosensing applications. In contrast to the well-known thiol-on-gold monolayers, the long-term hydrolytic, thermal, and electrochemical stability of the alkyne-Au bond remains relatively unexplored. Insight into these is, however, essential to deliver on the promise of the alkyne-Au bond for (bio)sensing applications, and to see under which conditions they might replace thiolate-gold bonds, if the latter are insufficiently stable due to, e.g., biological thiol exchange. Therefore, these stabilities were investigated for monolayers on Au substrates formed from 1-octadecanethiol

SUBMITTER: Yang Z 

PROVIDER: S-EPMC11912541 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature