Detecting Schistosoma infections in endemic countries: a diagnostic accuracy study in rural Madagascar.

ABSTRACT:

Background

Schistosoma haematobium and S. mansoni are endemic in Madagascar, but reliable diagnostic tools are often lacking, contributing to exacerbate transmission and morbidity. This study evaluated the diagnostic accuracy of three tests for schistosome infection in Malagasy adults from areas of medium to high endemicity.

Methods

This cross-sectional study enrolled adults from three primary health care centres in Madagascar. Urine and blood samples were tested for schistosome infection using polymerase chain reaction (PCR), up-converting reporter particle lateral flow for the circulating anodic antigen (UCP-LF CAA), and point-of-care circulating cathodic antigen (POC-CCA) tests. Bayesian latent class models were used to assess diagnostic accuracies and disease prevalence.

SUBMITTER: Lorenz E 

PROVIDER: S-EPMC11912594 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature