Associations between RetNet gene polymorphisms and the efficacy of orthokeratology for myopia control: a retrospective clinical study.

ABSTRACT:

Background

This study investigated how clinical and genetic factors impact the effectiveness of orthokeratology lenses in myopia.

Methods

A retrospective clinical study was conducted with a sample of 545 children aged 8-12 years who had myopia and have initially worn orthokeratology lenses for one year. Whole-genome sequencing (WGS) was also performed on 60 participants in two groups, one with rapid axial length (AL) progression of larger than 0.33 mm and the other with slow AL progression of less than 0.09 mm. The RetNet database was used to screen candidate genes that may contribute to the effectiveness of orthokeratology lenses in controlling myopia.

Results

Children with greater baseline AL, greater spherical equivalent (SE) and greater age had better myopia contr

SUBMITTER: Xia R 

PROVIDER: S-EPMC11912624 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature