The impact of different cervical planning target volume designs on efficacy and toxicity in nasopharyngeal carcinoma: a single-center retrospective study.

ABSTRACT:

Background

In nasopharyngeal carcinoma (NPC) patients, two radiation target delineation patterns are used for the cervical lymph node area.

Purpose

This study compares the efficacy and toxicity of two radiation target volume delineation patterns for planning target volumes (PTVs) in NPC patients.

Methods

This retrospective analysis included 387 non-metastatic NPC patients treated with concurrent chemoradiotherapy from January 2017 to December 2020. Patients were divided into two groups: the 2-PTV group with two dose gradients (50-54 Gy and 66-70 Gy) and the 3-PTV group with an additional 60-63 Gy dose.

Results

After a median follow-up of 51.2 months, the 3-year regional relapse-free survival (RRFS) showed no significant differences between the 3-PTV and 2-PTV g

SUBMITTER: Wang L 

PROVIDER: S-EPMC11912676 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature