Determinants of left atrial reservoir strain and diagnostic potential for cardiac amyloidosis in pathological left ventricular hypertrophy.

ABSTRACT:

Background

Left ventricular (LV) long-axis shortening at the cardiac base is a determinant of left atrial (LA) reservoir function. Cardiac amyloidosis (CA) is characteristic of amyloid deposition predominantly in the LV basal wall. We investigated the relationship between LV basal strain and LA reservoir strain among patients with pathological LV hypertrophy and subsequently evaluated the diagnostic ability of LA reservoir strain to identify CA etiology and its predictive value for heart failure hospitalization.

Methods

We retrospectively analyzed 341 patients with LV hypertrophy. Cardiac etiologies were diagnosed by tissue biopsy, cardiac magnetic resonance imaging or ^99mTc-PYP scintigraphy. LV basal strain and LA reservoir strain were analyzed.

Results

Pa

SUBMITTER: Inoue K 

PROVIDER: S-EPMC11912716 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature