Characteristics and clinical value of intestinal metabolites in 4 to 6-year-old children with OSAHS.

ABSTRACT:

Objective

This study aims to explore the characteristics and functional changes of intestinal metabolites in children with obstructive sleep apnea hypopnea syndrome (OSAHS) aged 4-6 years old through metabolomic approaches, screen potential biomarkers and analyze their correlation with clinical indicators and preliminary discuss the roles of intestinal metabolites in the occurrence and development of OSAHS.

Methods

We collected fecal samples from 40 OSAHS children and 40 healthy controls aged 4-6 years and recorded some OSAHS-related clinical indicators. Fecal specimens were used to detect all metabolites through untargeted metabolomics.

Results

This study identified a total of 1164 intestinal metabolites and screened out 254 differential metabolites. In the OSAHS gro

SUBMITTER: Lu Y 

PROVIDER: S-EPMC11912726 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature