Genetic insights into idiopathic pulmonary fibrosis: a multi-omics approach to identify potential therapeutic targets.

ABSTRACT:

Objective

To identify potential therapeutic targets and evaluate the safety profiles for Idiopathic Pulmonary Fibrosis (IPF) using a comprehensive multi-omics approach.

Method

We integrated genomic and transcriptomic data to identify therapeutic targets for IPF. First, we conducted a transcriptome-wide association study (TWAS) using the Omnibus Transcriptome Test using Expression Reference Summary data (OTTERS) framework, combining plasma expression quantitative trait loci (eQTL) data with IPF Genome-Wide Association Studies (GWAS) summary statistics from the Global Biobank (discovery) and Finngen (duplication). We then applied Mendelian randomization (MR) to explore causal relationships. RNA-seq co-expression analysis (bulk, single-cell and spatial transcriptomics) was used

SUBMITTER: Wen Z 

PROVIDER: S-EPMC11912729 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature