Early predictors of induction of remission with exclusive enteral nutrition in children with Crohn's disease.

ABSTRACT:

Background

Exclusive enteral nutrition (EEN) is recommended as first-line therapy for children with mild to moderate Crohn's disease (CD), given its effectiveness in inducing clinical remission (CR) and promoting mucosal healing (MH). However, the identification of reliable early predictors of EEN response remains an area requiring further investigation.

Methods

Patients with CD diagnosed between 2015 and 2024 were divided into training and validation cohorts. Baseline clinical and laboratory covariates were analyzed separately to evaluate their associations with CR and MH after 8 weeks of EEN therapy. Significant covariates were identified through univariate analysis and correlation tests, followed by their inclusion in stepwise logistic regression to develop separate predi

SUBMITTER: Hu Y 

PROVIDER: S-EPMC11912732 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature