Untargeted metabolomics reveals homogeneity and heterogeneity between physiological and pathological ovarian aging.

ABSTRACT:

Background

Ovarian aging is the main cause of reduced reproductive life span, yet its metabolic profiles remain poorly understood. This study aimed to reveal the metabolic homogeneity and heterogeneity between physiological and pathological ovarian aging.

Methods

Seventy serum samples from physiological ovarian aging participants, pathological ovarian aging participants (including diminished ovarian reserve (DOR), subclinical premature ovarian insufficiency (scPOI) and premature ovarian insufficiency (POI)), as well as healthy participants were collected and analyzed by untargeted metabolomics.

Results

Five homogeneous differential metabolites (neopterin, menaquinone, sphingomyelin (SM) (d14:1/24:2), SM (d14:0/21:1) and SM (d17:0/25:1)) were found in both physiologica

SUBMITTER: Zeng L 

PROVIDER: S-EPMC11912745 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature