Metabolic state uncovers prognosis insights of esophageal squamous cell carcinoma patients.

ABSTRACT:

Background

Metabolite-protein interactions (MPIs) are crucial regulators of cancer metabolism; however, their roles and coordination within the esophageal squamous cell carcinoma (ESCC) microenvironment remain largely unexplored. This study is the first to comprehensively map the metabolic landscape of the ESCC microenvironment by integrating an MPI network with multi-scale transcriptomics data.

Methods

First, we characterized the metabolic states of cells in ESCC using single-cell transcriptome profiles of key metabolite-interacting proteins. Next, we determined the metabolic patterns of each ESCC patient based on the composition of different metabolic states within bulk samples. Finally, the ESCC samples were clustered into unique subtypes.

Results

Sixteen ESCC meta

SUBMITTER: Feng T 

PROVIDER: S-EPMC11912770 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature