Protective effects of bone marrow mesenchymal stem cell-derived exosomes loaded cerium dioxide nanoparticle against deoxynivalenol-induced liver damage.

ABSTRACT:

Background

Deoxynivalenol (DON), a mycotoxin produced by Fusarium species, posed significant threats to food safety and human health due to its widespread prevalence and detrimental effects. Upon exposure, the liver, which played a crucial role in detoxifying DON, experienced depleted antioxidant levels and heightened inflammatory responses. Bone marrow mesenchymal stem cell (BMSC)-derived exosomes (BMSC-exos) exhibited therapeutic potential by promoting cellular repair and delivering bioactive substances, such as cerium dioxide nanoparticles (CeO₂ NPs), which are recognized for their ability to mitigate oxidative stress and inflammation.

Results

We successfully loaded BMSC-exos with CeO₂ NPs (BMSC-exos @ CeO₂) using extrusion techniques, verified throu

SUBMITTER: Meng Z 

PROVIDER: S-EPMC11912777 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature