Association of statin use with clinical outcomes in patients with triple-negative breast cancer.

ABSTRACT:

Background

Previous studies have examined the association of statin therapy and breast cancer outcomes with mixed results. The objective of this study was to investigate the clinical effects of incident statin use among individuals with triple-negative breast cancer (TNBC).

Methods

Data from the Surveillance, Epidemiology, and End Results-Medicare and Texas Cancer Registry-Medicare databases were used, and women aged ≥66 years who had stage I, II, and III breast cancer were identified. Multivariable Cox proportional hazards regression models were used to examine the association of new statin use in the 12 months after a breast cancer diagnosis with overall survival (OS) and breast cancer-specific survival (BCSS).

Results

When examining incident statin use, defined as

SUBMITTER: Nowakowska MK 

PROVIDER: S-EPMC11912801 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature