High-recombining genomic regions affect demography inference based on ancestral recombination graphs.

ABSTRACT: Multiple methods of demography inference are based on the ancestral recombination graph. This powerful approach uses observed mutations to model local genealogies changing along chromosomes by historical recombination events. However, inference of underlying genealogies is difficult in regions with high recombination rate relative to mutation rate due to the lack of mutations representing genealogies. Despite the prevalence of high-recombining genomic regions in some organisms, such as birds, its impact on demography inference based on ancestral recombination graphs has not been well studied. Here, we use population genomic simulations to investigate the impact of high-recombining regions on demography inference based on ancestral recombination graphs. We demonstrate that inference of effe

SUBMITTER: Ishigohoka J 

PROVIDER: S-EPMC11912872 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature