Multistate oral carcinogenesis-A prospective cohort study and a parallel case-control study in Taiwan.

ABSTRACT:

Background

To characterize multistate oral carcinogenesis, we conducted a cohort study of patients with oral precancer and a parallel case-control study of oral cancers and controls in Taiwan.

Methods

During 2013-2019, we recruited patients with oral precancer (n = 1998) or invasive oral cancer (n = 768) and hospital-based controls (n = 717). Precancer patients were followed up biannually for up to five years; questionnaire data and biospecimens were collected at multiple timepoints. Precancer natural history (regression/persistence, incidence, progression) was evaluated through follow-up visits and linkages with Taiwan's Cancer Registry.

Cohort updates

Cross-sectionally, 71 % of oral precancers and 62 % of cancers were attributable to betel-quid chewing, smoking, and

SUBMITTER: Wang CP 

PROVIDER: S-EPMC11912919 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature