The association between basal metabolic rate and ischemic stroke: a Mendelian randomization study.

ABSTRACT:

Objective

This study aims to elucidate the potential impact of basal metabolic rate on ischemic stroke at the genetic prediction level through a two-sample Mendelian randomization analysis.

Methods

Using summary data from genome-wide association studies, we obtained information on basal metabolic rate and ischemic stroke from a large-scale genome-wide association study. MR analysis used inverse variance weighting, weighted median, MR-Egger, simple mode, and weighted estimation. Sensitivity analyses, including the MR-Egger method, MR-PRESSO, Cochran's Q-test, and leave-one-out assessment, were performed to assess the reliability of the results.

Results

Genetic susceptibility to basal metabolic rate was significantly associated with ischemic stroke in multiple mo

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11912940 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature