Synthesis of α-substituted cyclic boronates <i>via</i> titanium-catalyzed cyclization of vinyl boronates with dihaloalkanes.

ABSTRACT: Cyclic boronates are versatile synthons for organic synthesis and for introducing ring systems into bioactive molecules. Existing synthetic methods have narrow substrate scope and the synthesis of α-substituted cyclic boronates is still elusive. Furthermore, no general method for synthesizing cyclic boronates with different ring sizes and hetero atom containing rings is available. Herein, we present a new and general synthetic method for synthesizing α-substituted cyclic boronates. Our approach has the advantage of using earth-abundant Ti as the catalyst and readily available dihaloalkanes, such as dichloromethane, as the reactant. Cyclic boronates that are otherwise difficult to access, such as α-substituted cyclic boronates with three-, four-, five-, and six-membered rings, heteroatom-co

SUBMITTER: Tian X 

PROVIDER: S-EPMC11913033 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature