Regulation of DNA methylation in lesional tissue of children with atopic dermatitis.

ABSTRACT:

Background

Genetic and epigenetic mechanisms have been shown to play a role in the pathogenesis of atopic dermatitis (AD). However, the role of genes involved in the establishment of DNA methylation has not yet been demonstrated.

Methods

A total of 15 pediatric patients with AD and 15 healthy volunteers were included in this study. The mRNA gene expression levels of eight different genes involved in the regulation of DNA methylation were examined in the blood and tissue samples.

Results

The mRNA expression levels of DNMT3A genes were significantly increased, while the mRNA expression levels of DNMT3B, TET1, and TET2 genes were statistically significantly reduced in the lesional tissue of patients compared to the control group. It was observ

SUBMITTER: Kartal D 

PROVIDER: S-EPMC11913172 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature