Medial ganglionic eminence transplantation restores inhibition after central visual system brain injury.

ABSTRACT: Inhibitory interneurons are critical regulators of visual circuit function and plasticity, but they are partially lost after brain injury. It has been hypothesized that embryonic medial ganglionic eminence (MGE) progenitors transplanted into visual cortex may facilitate brain repair, but there is no evidence that MGE cells modify inhibition in the damaged visual system. Here, we demonstrate that MGE progenitors transplanted into primary visual cortex of adult mice with traumatic brain injury (TBI) migrate widely throughout the lesioned area and express molecular markers of mature inhibitory interneurons. Whole-cell voltage-clamp recordings of inhibitory postsynaptic currents obtained from layer 2/3 host neurons, 45-60 days after transplantation, revealed a significant loss of GABA-mediated

SUBMITTER: Hou B 

PROVIDER: S-EPMC11913217 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature