Gut microbiome-driven regulation of sex hormone homeostasis: a potential neuroendocrine connection.

ABSTRACT: The gut microbiome is known to have a bidirectional relationship with sex hormone homeostasis; however, its role in mediating interactions between the primary regulatory axes of sex hormones and their productions is yet to be fully understood. We utilized both conventionally raised and gnotobiotic mouse models to investigate the regulatory role of the gut microbiome on the hypothalamic-pituitary-gonadal (HPG) axis. Male and female conventionally raised mice underwent surgical modifications as follows: (1) hormonally intact controls; (2) gonadectomized males and females; (3) gonadectomized males and females supplemented with testosterone and estrogen, respectively. Fecal samples from these mice were used to colonize sex-matched, intact, germ-free recipient mice through fecal microbiota tran

SUBMITTER: Organski AC 

PROVIDER: S-EPMC11913384 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature