Impact of ivermectin on nerve regeneration following sciatic injury in mice: the consequences of dietary high fructose.

ABSTRACT:

Background/aim

Peripheral nerve injuries (PNIs) are debilitating disorders affecting predominantly the younger generation, often leading to significant disabilities. Current treatment strategies are inadequate for addressing the complex nature of these injuries. Peripheral nerve healing and functional recovery are crucial components of both pathophysiology and therapeutic approaches. High fructose corn syrup (HFCS) is a sweetener frequently used in several beverages and foods. It is associated with several metabolic disturbances including insulin resistance and may impair nerve healing. This study investigated the therapeutic role of ivermectin on nerve regeneration following sciatic nerve injury and evaluated motor and sensorial functions together with histopathological evaluation

SUBMITTER: Arikan ED 

PROVIDER: S-EPMC11913497 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature