Effects of rapid weight loss on the body composition and pathophysiological mechanisms involved in obesity.

ABSTRACT: The Japan Society for the Study of Obesity recommends a weight loss of 3% of body weight over a period of 3-6 months. However, the effects of rapid weight loss on the body composition have not yet been adequately studied. Therefore, we observed the changes in the body composition induced by rapid weight loss and its effects on the pathophysiological mechanisms involved in obesity. The subjects were people with obesity admitted to our institution. The goal was to achieve a 3-5% body weight loss in the subjects by combining a carbohydrate-controlled therapeutic diet of 25-30 kcal/day per kg target body weight, exercise therapy, and pharmacotherapy. The body composition was measured at admission and at discharge by the dual bioelectrical impedance analysis. After 2 weeks, the participants' bo

SUBMITTER: Kadowaki Y 

PROVIDER: S-EPMC11913558 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature