The causal association between resting state intrinsic functional networks and neurodegeneration.

ABSTRACT: Alterations of resting state intrinsic functional networks have been associated with neurodegenerative diseases even before the onset of cognitive symptoms. Emerging hypotheses propose a role of resting state intrinsic functional networks alterations in the risk or vulnerability to neurodegeneration. It is unknown whether intrinsic functional network alterations can be causal for neurodegenerative diseases. We sought to answer this question using two-sample Mendelian randomization. Using the largest genome-wide association study of resting state intrinsic functional connectivity (n = 47 276), we generated genetic instruments (at the significance level 2.8 ×10^-11) to proxy resting state intrinsic functional network features. Based on the known brain regions implicated in d

SUBMITTER: Nassan M 

PROVIDER: S-EPMC11913654 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature