Incorporating polygenic risk into the Leicester Risk Assessment score for 10-year risk prediction of type 2 diabetes.

ABSTRACT:

Aims

We evaluated whether incorporating information on ethnic background and polygenic risk enhanced the Leicester Risk Assessment (LRA) score for predicting 10-year risk of type 2 diabetes.

Methods

The sample included 202,529 UK Biobank participants aged 40-69 years. We computed the LRA score, and developed two new risk scores using training data (80% sample): LRArev, which incorporated additional information on ethnic background, and LRAprs, which incorporated polygenic risk for type 2 diabetes. We assessed discriminative and reclassification performance in a test set (20% sample). Type 2 diabetes was ascertained using primary care, hospital inpatient and death registry records.

Results

Over 10 years, 7,476 participants developed type 2 diabetes. The Harrell's C ind

SUBMITTER: Liu X 

PROVIDER: S-EPMC11913737 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature