Transcriptomic and Histological Characterization of Telocytes in the Human Dorsal Root Ganglion.

ABSTRACT: Telocytes are interstitial cells characterized by long processes that span considerable distances within tissues, likely facilitating coordination and interaction with various cell types. Although present in central and peripheral neuronal tissues, their role remains elusive. Dorsal root ganglia (DRG) house pseudounipolar afferent neurons responsible for transmitting signals related to temperature, proprioception, and nociception. This study aimed to investigate the presence and function of telocytes in human DRG by examining their transcriptional profile, anatomical location, and ultrastructure. Combined expression of CD34 and PDGFRA is a marker gene set for telocytes, and our sequencing data revealed CD34 and PDGFRA expressing cells comprise roughly 1.5%-3% of DRG cells. Combined express

SUBMITTER: Haberberger RV 

PROVIDER: S-EPMC11913768 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature