Assessment of the causal association between obstructive sleep apnea and telomere length: a bidirectional mendelian randomization study.

ABSTRACT:

Background

A plethora of observational studies has established a significant correlation between Obstructive Sleep Apnea (OSA) and Telomere Length (TL). Nevertheless, a universal consensus on precise causal association and its directionality has not yet been achieved. To shed light on this, we employed Mendelian Randomization (MR) to investigate the bidirectional causal association between OSA and TL.

Method

Utilizing publicly accessible Genome-Wide Association Studies (GWAS) datasets, we procured genetic data pertinent to MR analysis. The study incorporated samples from both the OSA (n = 217,955) and TL (n = 472,174) cohorts. In the forward MR analysis, OSA served as the exposure variable and TL as the outcome. Conversely, the reverse MR analysis treated TL as the exposure

SUBMITTER: Xie R 

PROVIDER: S-EPMC11913802 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature