Prognostic value of preoperative and postoperative serum CEA in colorectal signet ring cell carcinoma.

ABSTRACT:

Background

Colorectal signet ring cell carcinoma (SRCC) is a rare and poorly prognosed tumor with limited established prognostic indicators. This study aims to investigate the prognostic value of serum carcinoembryonic antigen (CEA) in patients with colorectal SRCC.

Methods

A retrospective, multicenter study was conducted to assess the association between CEA levels and survival outcomes in 942 patients with colorectal SRCC.

Results

Patients exhibiting preoperative CEA (preCEA)-positivity demonstrated significantly lower cancer-specific survival (CSS) compared to those with preCEA-negativity in both Chinese and SEER datasets (5-year CSS: 27.50% vs. 48.27%, P = 0.01; 34.37% vs. 48.47%, P < 0.05). This disparity in outcomes was particularly notable in adva

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC11913837 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature