MRI characteristics predict risk of pathological upgrade in patients with ISUP grade group 1 prostate cancer.

ABSTRACT:

Objective

This study aims to analyse multiparametric MRI (mpMRI) characteristics of patients diagnosed with ISUP grade group (GG) 1 prostate cancer (PC) on initial target plus systematic MRI/TRUS fusion-guided biopsy and investigate histopathological progression during follow-up.

Methods

A retrospective single-centre cohort analysis was conducted on consecutive patients with mpMRI visible lesions (PI-RADS ≥ 3) and detection of ISUP-1-PC at the time of initial biopsy. The study assessed clinical, mpMRI, and histopathological parameters. Subcohorts were analysed with (1) patients who had confirmed ISUP-1-PC and (2) patients who experienced histopathological upgrading to ISUP ≥ 2 PC during follow-up either at re-biopsy or radical prostatectomy (RP).

Results

A total of 15

SUBMITTER: Boschheidgen M 

PROVIDER: S-EPMC11913941 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature