Temporal trends in time toxicity of R-CHOP: a nationwide hospital-based database analysis in Japan.

ABSTRACT:

Purpose

While the prognosis of patients with cancer has improved, the time burden of treatment has recently been recognized as time toxicity; although, the actual clinical situation remains largely unexplored. This retrospective study aimed to elucidate the time toxicity of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in patients with B-cell lymphoma and the factors influencing it.

Methods

We used a nationwide hospital-based database between January 2010 and November 2021 in Japan. We extracted the claims data of patients with diffuse large B-cell lymphoma and follicular lymphoma who were hospitalized and/or visited hospitals for chemotherapy.

Results

Among the 7760 R-CHOP administered to 2006 patients, the rate of outpatient therapy

SUBMITTER: Araie H 

PROVIDER: S-EPMC11913952 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature