Multi-scale dynamics influence the division potential of stomatal lineage ground cells in Arabidopsis.

ABSTRACT: During development, many precursor lineages are flexible, producing variable numbers and types of progeny cells. What determines whether precursors differentiate or continue dividing? Here we take a quantitative approach that combines long-term live imaging, statistical modeling and computational simulations to probe the developmental flexibility of stomatal lineage ground cells (SLGC) in Arabidopsis leaves. We discover that cell size is a strong predictor of SLGC behaviour and that cell size is linked to division behaviour at multiple spatial scales. At the neighbourhood scale, cell size correlates with the strength of cell-cell signaling, which affects the rate at which SPEECHLESS (SPCH), a division-promoting transcription factor, is degraded. At the subcellular scale, cell size correlat

SUBMITTER: Fung HF 

PROVIDER: S-EPMC11914061 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature