Neural basis of adolescent THC-induced potentiation of opioid responses later in life.

ABSTRACT: Use of one addictive drug typically influences the behavioral response to other drugs, either administered at the same time or a subsequent time point. The nature of the drugs being used, as well as the timing and dosing, also influence how these drugs interact. Here, we tested the effects of adolescent THC exposure on the development of morphine-induced behavioral adaptations following repeated morphine exposure during adulthood. We found that adolescent THC administration paradoxically prevented the development of anxiety-related behaviors that emerge during a forced abstinence period following morphine administration but facilitated reinstatement of morphine CPP. Following forced abstinence, we then mapped the whole-brain response to a moderate dose of morphine and found that adolescent

SUBMITTER: Hubbard E 

PROVIDER: S-EPMC11914220 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature