Requirements for fast multianalyte detection and characterisation via electrochemical-assisted SERS in a reusable and easily manufactured flow cell.

ABSTRACT: Surface-enhanced Raman spectroscopy (SERS) is a highly sensitive analytical technique that captures vibrational spectra of analytes adsorbed to rough coin metal surfaces with remarkable signal intensities. However, its wider application is limited by challenges in substrate range, quantification, and the disposable nature of SERS substrates partly due to irreversible analyte adsorption-commonly referred to as the 'memory effect'. Overcoming these limitations and achieving real-time analysis in flow-through systems remains a key challenge for the advancement of SERS. This study presents a SERS flow cell incorporating an Ag-based SERS substrate and a Pt counter-electrode, enabling the investigation of how electrochemical methods can address existing challenges. Our approach demonstrates that

SUBMITTER: Blaha ME 

PROVIDER: S-EPMC11914304 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature