The RNA-binding protein KSRP reduces asthma-like characteristics in a murine model.

ABSTRACT:

Background and objective

Asthma is a chronic inflammatory disease characterized by dysregulated cytokine expression. The RNA-binding protein KSRP reduces the expression of several pro-inflammatory mediators. Therefore, we investigated whether KSRP modulates Th2-associated immune responses in vivo in an ovalbumin-induced (OVA) allergic asthma model in C57BL/6 KSRP-deficient mice (KSRP^-/-).

Methods

Asthma severity in OVA-immunized wild type or KSRP^-/- mice was determined by airway hyperresponsiveness (AHR), structural changes of lung tissue, and OVA-specific antibody production. Cytokine expression in bronchoalveolar lavage fluid (BALF) was measured by Cytometric Bead Array (CBA) analysis. Cellular signaling pathways involved in KSRP-mediated effects in a

SUBMITTER: Palzer KA 

PROVIDER: S-EPMC11914311 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature