Shift of cell-death mechanisms in primary human neutrophils with a ruthenium photosensitizer.

ABSTRACT: Primary human neutrophils are the most abundant human white blood cells and are central for innate immunity. They act as early responders at inflammation sites, guided by chemotactic gradients to find infection or inflammation sites. Neutrophils can undergo both apoptosis as well as NETosis. NETosis is a form of neutrophil cell death that releases chromatin-based extracellular traps (NETs) to capture and neutralize pathogens. Understanding or controlling the balance between these cell-death mechanisms is crucial. In this study, the chemical synthesis and biologic assessment of a ruthenium complex as a light-activated photosensitizer that creates reactive oxygen species (ROS) in primary human neutrophils is reported. The ruthenium complex remains non-toxic in the dark. However, upon exposur

SUBMITTER: Montesdeoca N 

PROVIDER: S-EPMC11914334 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature