A novel prognostic signature based on m5C‑related LncRNAs and its immunological characteristics in colon adenocarcinoma.

ABSTRACT:

Background

Colon adenocarcinoma (COAD) has high mortality rates due to frequent resistance to treatment. 5-methylcytosine (m5C) is a crucial epigenetic modification of RNA, closely associated with tumorigenesis in various cancers. This study focuses on developing an m5C-related long non-coding RNA (lncRNA) signature to predict prognosis and explore potential therapeutic targets.

Methods

Using data from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO), we analyzed 18 m5C regulatory genes and their associated lncRNAs in COAD samples. Prognostic lncRNAs were identified through univariate Cox regression, and a risk model was constructed through LASSO regression analyses. Kaplan-Meier survival and receiver operating characteristic analyses were employed to val

SUBMITTER: Liu Z 

PROVIDER: S-EPMC11914420 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature