Risk Factors for Empiric Treatment Failure in US Female Outpatients with Uncomplicated Urinary Tract Infection: an Observational Study.

ABSTRACT:

Background

Treatment failure (TF) in uncomplicated urinary tract infection (uUTI) increases disease burden and risk of antimicrobial resistance. Identification of risk factors for TF could inform empiric treatment decisions and reduce suboptimal outcomes.

Objective

To evaluate the incidence of TF to empirically prescribed oral antibiotics and identify risk factors for TF in females with uUTI in the United States (US).

Design

This retrospective cohort study used Optum's de-identified Electronic Health Record dataset (January 2017-September 2022).

Patients

Eligible female patients aged ≥ 12 years had ≥ 1 diagnosis of urinary tract infection (UTI) in an outpatient ambulatory/emergency department (ED) setting, ≥ 1 empiric oral antibiotic prescription, and no eviden

SUBMITTER: Fromer DL 

PROVIDER: S-EPMC11914431 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature