Endocannabinoid contributions to the perception of socially relevant, affective touch in humans.

ABSTRACT: Social relationships are central to well-being. A subgroup of afferent nerve fibers, C-tactile (CT) afferents, are primed to respond to affective, socially relevant touch and may mitigate the effects of stress. The endocannabinoid ligand anandamide (AEA) modulates both social reward and stress. We thus hypothesized that AEA levels would be associated with the perceived pleasantness of affective touch in humans. Across two studies, we explored perceptions of affective, socially relevant touch and general affective stimuli. In study 1, adult participants (N = 101) were recruited based on presence (CM+) or absence (CM-) of documented childhood maltreatment (N = 52 CM+; N = 49 CM-). In study 2, healthy individuals were randomized to receive an inhibitor of fatty acid amide hydrolase (FAAH; PF-

SUBMITTER: Jones MR 

PROVIDER: S-EPMC11914470 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature