Blood pressure waveform morphology assessed using a transmission line model and harmonic distortion analysis.

ABSTRACT: A major determinant of blood pressure waveform (BPW) morphology is vascular impedance, governed by material properties of the arterial wall and hemodynamics of blood flow. Analysis of BPW morphology can be an effective means of assessing cardiovascular health. A transmission line model of the mechanical impedance of the arterial tree was implemented to recreate physiologically realistic BPWs. We then examined the sensitivity of existing vascular measures, including augmentation index (AI), pulse wave velocity (PWV), and the recently proposed harmonic distortion (HD), to structural and mechanical parameters of vessel walls and blood flow. All three measures are primarily sensitive to structural stiffness while HD and AI also correlate strongly with geometric parameters. Further, in a simula

SUBMITTER: Milkovich N 

PROVIDER: S-EPMC11914491 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature