A Systematic Review of Antibiotic Administration Incidents Involving Neuraxial Routes: Clinical Analysis, Contributing Factors and Prevention Approaches.

ABSTRACT:

Introduction

This review aimed to investigate the inadvertent administration of antibiotics via epidural and intrathecal routes. The secondary objective was to identify the contributing human and systemic factors.

Methods

PubMed, Scopus and Google Scholar databases were searched for the last five decades (1973-2023). The author recorded the antibiotics involved, the route of administration, clinical details and consequences in a standardised format. The author utilized the Human Factors Analysis Classification System (HFACS) framework to identify contributing factors.

Results

Twenty publications reported neuraxial administration of antibiotics (adults, 19, paediatric, three patients). Fifteen (of 22) incidents happened in the post-surgical or post-chronic pain procedu

SUBMITTER: Patel S 

PROVIDER: S-EPMC11914543 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature