Loss of Cep135 causes oligoasthenoteratozoospermia and male infertility in mice.

ABSTRACT: Centrosomal proteins (Cep), as crucial scaffolding molecules, play a pivotal role in the biogenesis of centrioles and the regulation of the cell cycle. To date, mutation in Cep135 has been reported to be closely associated with multiple morphological abnormalities of the flagella (MMAF) in humans. However, the specific mechanism of Cep135 in spermatogenesis and its detailed role in male infertility remains largely unexplored. In this study, we present compelling evidence that Cep135 functions as a pathogenic gene responsible for oligoasthenoteratozoospermia (OAT) and male infertility in mice. By selectively deleting Cep135 in premeiotic germ cells using Stra8-Cre mice crossed with Cep135^flox/flox mice, we observed that Cep135 knockdown produced abnormal sperm morphology, germ ce

SUBMITTER: Liu H 

PROVIDER: S-EPMC11914644 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature